RNA Details
Disease Name
skin fibrosis
Tissue
skin
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
dysregulation
Species
homo sapiens
Detection Methods
immunofluorescence; qRT-PCR etc.
Target
NA
Pathway
NA
PubMed ID
Title
Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH
Year
2020
Function
Our data indicate that the ezh2-dependent epigenetic phenotype of myofibroblasts is driven by hotair and is linked to mirna-34a repression-dependent activation of notch signalling.